Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy
| Autor: | Richard Apps, Rui André Saraiva Raposo, Miguel de Mulder Rougvie, Talia M. Mota, R. Brad Jones, Douglas F. Nixon, Nathaniel D. Bachtel, Greta A. Beckerle |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Virus Cultivation Immunology Gene Expression HIV Infections Biology Virus 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation T-Lymphocyte Subsets Virology Gene expression medicine Humans Immunologic Factors 030212 general & internal medicine APOBEC3G Gene Expression Profiling ISG15 Gene expression profiling 030104 developmental biology Infectious Diseases medicine.anatomical_structure Anti-Retroviral Agents HIV-1 Viral load Memory T cell |
| Zdroj: | AIDS research and human retroviruses. 35(1) |
| ISSN: | 1931-8405 |
| Popis: | Much has been learnt from the functions of host restriction factors during acute and chronic HIV-1 infection, but far less is known about their role in HIV-1-infected individuals in which viral load is stably suppressed with antiretroviral therapy (ART). In this study transcriptional expression of 42 host restriction factors was determined for memory CD4+ T cells sorted from 10 uninfected and 21 HIV-1-infected individuals, treated with suppressive ART and for which the viral reservoir was quantified. No significant associations were observed between restriction factor expression and HIV-1 reservoir size, quantified by measurement of HIV-1 Gag DNA using droplet digital polymerase chain reaction, and by measurement of replication-competent inducible virus using quantitative viral outgrowth assays. Expression of eight of the restriction factors differed significantly, and with a false discovery rate of |
| Databáze: | OpenAIRE |
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