Prevention of herpes simplex virus infection and latency by prophylactic treatment with acyclovir in a weanling mouse model
| Autor: | Bertis B. Little, LL Scott, Anthony T. Dobson |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Time Factors
viruses Weanling Acyclovir Weaning medicine.disease_cause Antiviral Agents Virus Herpesviridae Mice Alphaherpesvirinae medicine Animals Aciclovir biology business.industry Obstetrics and Gynecology Herpes Simplex biology.organism_classification beta-Galactosidase Virology Virus Latency Mice Inbred C57BL Herpes simplex virus Viral replication Immunology Viral disease business medicine.drug |
| Zdroj: | American journal of obstetrics and gynecology. 179(2) |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: Acyclovir is an antiviral agent that inhibits acute herpes simplex virus replication and decreases the frequency of reactivation, but it is not currently used to prevent primary disease or the establishment of latency. The purpose of this study was to reexamine the efficacy of acyclovir in preventing acute and latent herpes simplex virus infection. STUDY DESIGN: Mice were infected by footpad inoculation with 2 viral recombinants that express β-galactosidase. Half of each group was treated prophylactically with intraperitoneal acyclovir and then given acyclovir in the drinking water. Four days after infection, the dorsal root ganglia were removed, fixed, and stained, and the number of cells expressing β-galactosidase were counted. RESULTS: Compared with placebo, prophylactic acyclovir completely inhibited acute viral replication as evidenced by the absence of β-galactosidase activity ( P P = .01). CONCLUSION: Acyclovir prophylaxis prevented acute and reduced latent ganglionic infection with herpes simplex virus in a weanling mouse model. (Am J Obstet Gynecol 1998;179:527-32.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect