Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice
| Autor: | Masanao Takahashi, Mikio Yamazaki, Ken Yasukawa, Michio Takido, Ken-ichi Kawai, Shinsaku Natori, Mieko Takeuchi |
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| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
Skin Neoplasms Ratón 9 10-Dimethyl-1 2-benzanthracene Inflammation 12-O-Tetradecanoylphorbol-13-acetate medicine.disease_cause chemistry.chemical_compound Pigment Mice medicine Animals Anticarcinogenic Agents Benzopyrans Hypersensitivity Delayed Mice Inbred ICR Chaetomium globosum biology business.industry General Medicine Monascus biology.organism_classification Molecular biology Oncology chemistry visual_art Immunology visual_art.visual_art_medium Tetradecanoylphorbol Acetate Tumor promotion Dinitrofluorobenzene Female medicine.symptom business Carcinogenesis |
| Zdroj: | Oncology. 51(1) |
| ISSN: | 0030-2414 |
| Popis: | Monascorubrin (an azaphilone derivative) was isolated from Monascus anka, 'Monascus pigment', a natural pigment of food additivies, was extracted from Monasucs spp., and chaetoviridin A, one of the azaphilones, was isolated from Chaetomium globosum var. flavo-viridae. Application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor promoting agent, to the mouse ear resulted in induction of inflammation. Among monascorubrin and related compounds assayed, monascorubrin, chaetoviridin A and its related compounds inhibited the inflammatory activity of TPA in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.4-1.5 mumol. Furthermore, monascorubrin (2 mumol), chaetoviridin A (2 mumol) and Monascus pigment (1 mg) markedly suppressed the promoting effect of TPA (1 microgram) on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene (50 micrograms). It is assumed that the inhibition of tumor promotion by monascorubrin, chaetoviridin A and Monascus pigment is due to anti-inflammatory activity. |
| Databáze: | OpenAIRE |
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