Pharmacological and Molecular Characterization of 5-Hydroxytryptamine 7 Receptors in the Rat Adrenal Gland
| Autor: | Sebastien Lenglet, Isabelle Lihrmann, Luca Grumolato, V. Contesse, Youssef Anouar, Hubert Vaudry, Catherine Delarue, Hervé Lefebvre |
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| Přispěvatelé: | Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Neuroendocrinologie cellulaire et moléculaire, Lihrmann, Isabelle, Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty [SDV]Life Sciences [q-bio] Blotting Western Biology 03 medical and health sciences Estrogen-related receptor alpha chemistry.chemical_compound 0302 clinical medicine Western blot Internal medicine Complementary DNA Adrenal Glands medicine Animals RNA Messenger Rats Wistar Receptor Aldosterone 030304 developmental biology Pharmacology 0303 health sciences medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction Adrenal cortex Molecular biology Rats Serotonin Receptor Agonists 3. Good health [SDV] Life Sciences [q-bio] Endocrinology medicine.anatomical_structure chemistry Mechanism of action Receptors Serotonin Molecular Medicine Serotonin Antagonists Serotonin medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Molecular Pharmacology Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 1999, 56 (3), pp.552-561. ⟨10.1124/mol.56.3.552⟩ Publons Molecular Pharmacology, 1999, 56 (3), pp.552-561. ⟨10.1124/mol.56.3.552⟩ |
| ISSN: | 0026-895X |
| Popis: | International audience; Serotonin (5-hydroxytryptamine; 5-HT) is a potent stimulator of aldosterone secretion in the rat adrenal gland but the type of receptor involved in the mechanism of action of 5-HT remains unknown. The aim of the present study was to determine the pharmacological profile and to clone the receptor responsible for the corticotropic effect of 5-HT in rat glomerulosa cells. A series of 10 serotonergic receptor agonists and 12 receptor antagonists was used to characterize the receptor mediating the effect of 5-HT on aldosterone secretion from perifused rat adrenocortical slices. Correlation analysis between the potencies of the different compounds in our model and those previously reported for various recombinant 5-HT receptors showed that the rat adrenal 5-HT receptor exhibits the same pharmacological profile as the 5-HT(7) receptor transiently expressed in COS-7 cells (r = 0.82 for agonists, p |
| Databáze: | OpenAIRE |
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