Teratogenic action and embryo lethality of AY 9944R: Prevention by a hypercholesterolemia-provoking diet
| Autor: | Rolande Dupuis, Charles Roux, Cécilia Horvath |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Cholesterol synthesis Embryology medicine.medical_specialty Health Toxicology and Mutagenesis Hypercholesterolemia Biology Toxicology trans-1 4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride Cholesterol Dietary Holoprosencephaly Cyclohexanes Pregnancy Internal medicine medicine Animals Fetal Death Fetus Abnormalities Drug-Induced Brain Embryo medicine.disease Rats Cholesterol Endocrinology Action (philosophy) Urogenital Abnormalities Female Lethality Holoprosencephalies Developmental Biology |
| Zdroj: | Teratology. 19:35-38 |
| ISSN: | 1096-9926 0040-3709 |
| Popis: | Embryomortality and teratogenesis provoked by inhibitors of cholesterol synthesis are well demonstrated. Teratogenic action is particularly reflected by holoprosencephalies, but also by uro-genital abnormalities. A hypercholesterolemia-provoking diet has been shown to be completely effective for preventing holoprosencephaly, but only partially so for preventing the uro-genital malformations and fetal mortality. It is thus possible that the two types of abnormalities are governed by different mechanisms. In addition, the diet itself, whose hypercholesterolemic effect is considerable, has certain disadvantages. It seems to have a certain effect on fetal mortality and could be responsible for several uro-genital malformations. This deserves further study. |
| Databáze: | OpenAIRE |
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