Abnormal center of mass feedback responses during balance: A potential biomarker of falls in Parkinson's disease
| Autor: | Sistania M. Bong, Kimberly C. Lang, J. Lucas McKay, Madeleine E. Hackney, Lena H. Ting, Stewart A. Factor |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Kinematics Parkinson's disease Velocity Social Sciences Medical Conditions Elderly Medicine and Health Sciences Psychology Muscle activity Postural Balance Movement Disorders Multidisciplinary Physics Classical Mechanics Neurodegenerative Diseases Parkinson Disease Middle Aged Bioassays and Physiological Analysis Neurology Physical Sciences Medicine Sensory Perception Female Muscle Electrophysiology Research Article Antagonist muscle Science Acceleration Research and Analysis Methods Motion medicine Adults Humans Aged Balance (ability) Balance and Falls Electromyography business.industry Electrophysiological Techniques Work (physics) Cognitive Psychology Antagonist Biology and Life Sciences medicine.disease Geriatrics Age Groups Potential biomarkers People and Places Cognitive Science Perception Population Groupings business Neuroscience Biomarkers |
| Zdroj: | PLoS ONE, Vol 16, Iss 5, p e0252119 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Although Parkinson disease (PD) causes profound balance impairments, we know very little about how PD impacts the sensorimotor networks we rely on for automatically maintaining balance control. In young healthy people and animals, muscles are activated in a precise temporal and spatial organization when the center of body mass (CoM) is unexpectedly moved that is largely automatic and determined by feedback of CoM motion. Here, we show that PD alters the sensitivity of the sensorimotor feedback transformation. Importantly, sensorimotor feedback transformations for balance in PD remain temporally precise, but become spatially diffuse by recruiting additional muscle activity in antagonist muscles during balance responses. The abnormal antagonist muscle activity remains precisely time-locked to sensorimotor feedback signals encoding undesirable motion of the body in space. Further, among people with PD, the sensitivity of abnormal antagonist muscle activity to CoM motion varies directly with the number of recent falls. Our work shows that in people with PD, sensorimotor feedback transformations for balance are intact but disinhibited in antagonist muscles, likely contributing to balance deficits and falls. |
| Databáze: | OpenAIRE |
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