Local tumour control and radiation side effects for fractionated stereotactic photon beam radiotherapy compared to proton beam radiotherapy in uveal melanoma
| Autor: | Wishal D. Ramdas, Emine Kilic, Roger D. Errington, Andrzej Kacperek, Bertil Damato, Heinrich Heimann, Martina Angi, Caroline M. van Rij, Jackelien G.M. van Beek, Nicole C. Naus |
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| Přispěvatelé: | Ophthalmology, Radiotherapy, Clinical Genetics |
| Rok vydání: | 2021 |
| Předmět: |
Uveal Neoplasms
Side effect medicine.medical_treatment Ocular Melanoma Enucleation Radiosurgery Eye Enucleation 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Humans Medicine Radiology Nuclear Medicine and imaging Melanoma Netherlands Retrospective Studies business.industry Retrospective cohort study Hematology medicine.disease United Kingdom eye diseases Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Maculopathy Neoplasm Recurrence Local Protons Nuclear medicine business Optic disc |
| Zdroj: | Radiotherapy and Oncology, 157, 219-224. Elsevier Ireland Ltd |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2021.01.030 |
| Popis: | Purpose: To compare the adverse side effects of fractionated stereotactic photon beam radiotherapy (fSRT) with proton beam radiotherapy (PBR) in patients with uveal melanoma (UM). Methods: A retrospective study investigating 306 UM patients treated with fSRT (N=153) by the Rotterdam Ocular Melanoma Study group (ROMS), The Netherlands, between 1999–2014 or with PBR (N=153) at the Royal Liverpool University Hospital and the Clatterbridge Cancer Centre, Bebington, United Kingdom, between 1993–2014. The tumours treated with fSRT were matched with tumours treated with PBR based on sex, left or right eye, TNM classification, posterior margin ≤ or > 3mm of the fovea and of the optic disc. Results: The five-year actuarial rates of tumour recurrence were 4.5% for fSRT and 6.1% for PBR. For fSRT and PBR, the five-year actuarial rates of maculopathy were 14.9% and 12.4%, and for vitreous haemorrhage were 29.4% and 4.7%, respectively. Only vitreous haemorrhage (HR: 0.19, 95% CI: 0.07–0.56) was more common after fSRT compared to PBR. Overall, larger tumours were risk factors for maculopathy and secondary enucleation. Conclusions: Both treatments have excellent local tumour control. In matched groups, vitreous haemorrhage was the only adverse side effect showing a significant difference between groups. |
| Databáze: | OpenAIRE |
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