3 Tesla-Diffusion Tensor Imaging in Autosomal Dominant Polycystic Kidney Disease: The Nephrologist's Point of View
| Autor: | Silvia Marino, Antonio Lacquaniti, Marcello Longo, Placido Bramanti, Michele Buemi, Rosaria Lupica, Biagio Bianchimano, Domenico Trimboli, Enricomaria Mormina, Francesca Granata |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Nephrology
Adult Male Pathology medicine.medical_specialty Autosomal dominant polycystic kidney disease Renal function Kidney Volume 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Kidney function Internal medicine Kidney volume Medicine Humans Prospective Studies Magnetic resonance image medicine.diagnostic_test business.industry Autosomal dominant polycystic kidney disease Magnetic resonance image Kidney disease Kidney function Kidney volume Biomarkers Magnetic resonance imaging Middle Aged Kidney disease medicine.disease Polycystic kidney Polycystic Kidney Autosomal Dominant Diffusion Tensor Imaging Female business 030217 neurology & neurosurgery Biomarkers Diffusion MRI |
| Popis: | Background/Aims: CT, MRI and ultrasound are currently used for screening and follow-up of individuals affected by autosomal dominant polycystic kidney disease (ADPKD). Dynamic contrast-enhanced MRI studies renal perfusion after gadolinium administration, with possible side effects, such as nephrogenic systemic fibrosis. The aim of our study was to evaluate the clinical application of 3 Tesla (3T)-diffusion tensor image (DTI) in ADPKD patients, correlating its parameters, such as fractional anisotropy (FA), and apparent diffusion coefficient (ADC) with kidney function tests. Methods: Eight ADPKD patients and 6 healthy volunteers (HS) were enrolled. FA and ADC mean values were calculated. And correlations between DTI-parameters, creatinine and estimated glomerular filtration rate (eGFR) were evaluated. Results: Parenchymal FA was significantly lower in ADPKD than HS (FA: 0.17 ± 0.03 vs. 0.22 ± 0.01; p = 0.02), whereas parenchymal ADC was higher in patients than controls (2.48 (×10-3) ± 0.16 vs. 2.28 (×10-3) ± 0.09), but a statistically significant difference was not achieved (p = 0.27). Direct correlations were revealed between eGFR and FA (r = 0.82; p = 0.0003), whereas an inverse correlation was found with creatinine (r = -0.77; p = 0.001). Similarly, ADC closely correlated with creatinine (r = 0.79; p = 0.0006) and eGFR (r = -0.620; p = 0.01). Conclusion: 3T-DTI is a promising radiological tool that could be used by nephrologists to evaluate ADPKD patients, highlighting early micro-structure alterations, without side effects and contrast agent administration. |
| Databáze: | OpenAIRE |
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