Comparative and Combinatorial Effects of Resveratrol and Sacubitril/Valsartan alongside Valsartan on Cardiac Remodeling and Dysfunction in MI-Induced Rats
| Autor: | Liping Yu, Jeffrey T. Wigle, Shelley Zieroth, Thomas Netticadan, Karen Sayfee, Mihir Parikh, Pema Raj |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Myocardial Infarction Pharmaceutical Science Organic chemistry heart failure Pharmacology Resveratrol resveratrol Sacubitril Ventricular Function Left Article Analytical Chemistry Rats Sprague-Dawley chemistry.chemical_compound QD241-441 Drug Discovery medicine Animals Humans Drug Interactions Myocardial infarction Physical and Theoretical Chemistry Ejection fraction Ventricular Remodeling business.industry Aminobutyrates Biphenyl Compounds food and beverages medicine.disease Brain natriuretic peptide Fibrosis Rats Drug Combinations Oxidative Stress Valsartan chemistry Chemistry (miscellaneous) Heart failure sacubitril/valsartan Molecular Medicine business Sacubitril Valsartan medicine.drug |
| Zdroj: | Molecules Volume 26 Issue 16 Molecules, Vol 26, Iss 5006, p 5006 (2021) |
| ISSN: | 1420-3049 |
| Popis: | The development and progression of heart failure (HF) due to myocardial infarction (MI) is a major concern even with current optimal therapy. Resveratrol is a plant polyphenol with cardioprotective properties. Sacubitril/valsartan is known to be beneficial in chronic HF patients. In this study, we investigated the comparative and combinatorial benefits of resveratrol with sacubitril/valsartan alongside an active comparator valsartan in MI-induced male Sprague Dawley rats. MI-induced and sham-operated animals received vehicle, resveratrol, sacubitril/valsartan, valsartan alone or sacubitril/valsartan + resveratrol for 8 weeks. Echocardiography was performed at the endpoint to assess cardiac structure and function. Cardiac oxidative stress, inflammation, fibrosis, brain natriuretic peptide (BNP), creatinine and neutrophil gelatinase associated lipocalin were measured. Treatment with resveratrol, sacubitril/valsartan, valsartan and sacubitril/valsartan + resveratrol significantly prevented left ventricular (LV) dilatation and improved LV ejection fraction in MI-induced rats. All treatments also significantly reduced myocardial tissue oxidative stress, inflammation and fibrosis, as well as BNP. Treatment with the combination of sacubitril/valsartan and resveratrol did not show additive effects. In conclusion, resveratrol, sacubitril/valsartan, and valsartan significantly prevented cardiac remodeling and dysfunction in MI-induced rats. The reduction in cardiac remodeling and dysfunction in MI-induced rats was mediated by a reduction in cardiac oxidative stress, inflammation and fibrosis. |
| Databáze: | OpenAIRE |
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