Thyroid stimulating hormone levels rise after assisted reproductive technology

Autor: Einat Shalom-Paz, David Morris, Baris Ata, Belen Herrero, Amir Wiser, José A. Correa, Shauna Reinblatt, Hananel Holzer
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı., Ata, Barış
Rok vydání: 2013
Předmět:
Infertility
female
Pregnancy test
History
endocrine system diseases
medicine.medical_treatment
Levothyroxine
Thyrotropin
Physiology
Autoimmunity
Controlled ovarian hyperstimulation
Thyrotropin blood level
Pregnancy
Thyroid stimulating hormone
Euthyroid women
Obstetrics & gynecology
Disease
Female infertility
Treatment outcome
Assisted Reproduction Technologies
Genetics (clinical)
Priority journal
Estradiol
Infertility therapy
Thyroid disease
Genetics & heredity
Obstetrics and Gynecology
General Medicine
Ovarian hyperstimulation
Assisted reproductive technology
Thyroid antibody
Anti-thyroid autoantibodies
Estradiol blood level
Body mass
Cohort studies
Female
Cohort analysis
Thyroid function
hormones
hormone substitutes
and hormone antagonists
Human
Adult
endocrine system
medicine.medical_specialty
Ovulation induction
Endometriosis
Reproductive biology
Antithyroid antibodies
Major clinical study
Article
Pregnancy outcome
Pregnancy rate
Hypothyroidism
Thyroid-stimulating hormone
Internal medicine
Genetics
medicine
Humans
Prospective study
Ovarian reserve
Reproductive techniques
assisted
business.industry
Ovary hyperstimulation
Embryo transfer
medicine.disease
Iodine Deficiency
Thyroid Function
Thyroxine
Endocrinology
Reproductive Medicine
Dysfunction
business
Prospective studies
Developmental Biology
Zdroj: Journal of Assisted Reproduction and Genetics. 30:1347-1352
ISSN: 1573-7330
1058-0468
DOI: 10.1007/s10815-013-0081-3
Popis: The goal of this study was to determine whether high E2 levels after controlled ovarian hyperstimulation affect TSH. Patients completing ART cycles between April-October 2010 were eligible for this cohort study. 180 patients were recruited however those with known thyroid disease were excluded. The final analysis included 154 subjects. Blood was collected at each visit during the ART cycle as well as at the pregnancy test. Samples were frozen at -20 A degrees C and analyzed together for E2 and TSH using the same assay kit once all patients had completed their cycles. All participants were treated at the McGill University Health Center. A paired t-test was used to study the difference in TSH levels recorded at maximal and minimal Estradiol levels during ovarian stimulation. Multiple regression analysis was then used to determine if factors such as anti-thyroid antibodies and ovarian reserve measures affect this change in TSH. We used multiple imputation methods to account for missing data. As E2 levels rose from low to supra-physiologic levels during treatment, TSH levels also rose significantly. This increase was clinically significant by the time of pregnancy test. The factors that potentially affected the change in TSH were: male factor/tubal factor infertility, type of protocol used as well as the presence of thyroid antibodies. Although TSH increases during ART, this change only becomes clinically significant on the day of pregnancy test. Future studies should examine TSH changes specifically in certain "at-risk" sub-groups such as those with antibodies and known thyroid disease. "Academic Enrichment Fund" of the Department of Obstetrics and Gynecology, McGill University, Montreal, Canada
Databáze: OpenAIRE
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