Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population

Autor: S. M. Moazzem Hossen, Mohammad Shahriar, Anika Uddin Hridy, Mohammad Safiqul Islam, Samia Shabnaz, Mohiuddin Ahmed Bhuiyan, Md. Asaduzzaman, Talha Bin Emran
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
XRCC2
Colorectal cancer
Gastroenterology
PCR-RFLP
0302 clinical medicine
Bangladeshi population
Polymorphism (computer science)
Risk Factors
Genotype
genetic polymorphism
Aged
80 and over
education.field_of_study
Bangladesh
General Medicine
Middle Aged
Prognosis
DNA-Binding Proteins
030220 oncology & carcinogenesis
Female
Colorectal Neoplasms
Research Article
Adult
medicine.medical_specialty
Adolescent
Population
Polymorphism
Single Nucleotide
03 medical and health sciences
Young Adult
Internal medicine
Genetic variation
medicine
Humans
Genetic Predisposition to Disease
Risk factor
education
Aged
business.industry
Case-control study
Heterozygote advantage
medicine.disease
030104 developmental biology
Case-Control Studies
RAD51
Rad51 Recombinase
business
Follow-Up Studies
Zdroj: Asian Pacific Journal of Cancer Prevention : APJCP
ISSN: 2476-762X
1513-7368
Popis: Objectives In case of Bangladeshi population, no report is observed till now showing the genetic variations of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism having association with colorectal cancer risk. For this reason the aim of this study is to ascertain their interrelation with colorectal cancer occurrence in Bangladeshi population. Materials and methods A case control study was conducted where 200 colorectal cancer patients and 200 healthy volunteers were figured for this research using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results Here, in case of RAD51 (rs1801320), G/C heterozygous genotype was found significant (p=0.037; OR=1.64; 95% CI=1.03 to 2.6). On the other hand, G/G genotype was not found statistically significant (p=0.423; OR=1.61; 95% CI=0.49 to 5.22) and significance was observed for GC+GG (p=0.030; OR=1.63; 95% CI=1.05 to 2.55). In case of XRCC2 (rs3218536), C/T heterozygous genotype was remarked statistically significant (p=0.033; OR=1.60; 95% CI=1.04 to 2.46). The T/T genotype was not recorded statistically significant (p=0.237; OR=1.65; 95% CI=0.72 to 3.76) but significance found for CT+TT (p=0.027; OR=1.61; 95% CI=1.05 to 2.45). Moreover, it is found that the risk factor of developing CRC is observed in G/C, C/T heterozygote and GC+GG, CT+TT (heterozygote+ mutant) in RAD51 (rs1801320) and XRCC2 (rs3218536) respectively although no significance is observed in case of G/G and T/T mutant. Conclusions So, the association of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism with colorectal cancer risk is observed in Bangladeshi population.
Databáze: OpenAIRE
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