Magnetic resonance angiography-derived flow parameters to assess thoracic aortic disease risk
Autor: | Fabian A Kari, Maximilian F Russe, Christopher L Schlett |
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Rok vydání: | 2021 |
Předmět: |
Aortic dilatation
4D flow MRI Pulmonary and Respiratory Medicine Eacts/144 Aortic Aneurysm Thoracic AcademicSubjects/MED00920 Eacts/161 Aorta Thoracic General Medicine Wall shear stress Flow displacement Humans Ascending aorta Surgery Cardiology and Cardiovascular Medicine Magnetic Resonance Angiography Endovascular Aortic Surgery Eacts/125 |
Zdroj: | European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery |
ISSN: | 1873-734X 1010-7940 |
Popis: | OBJECTIVES Our goal was to evaluate whether four-dimensional (4D) flow magnetic resonance imaging (MRI) can predict the growth rate of dilatation of the ascending aorta (AA) in patients with a tricuspid, normally functioning aortic valve. METHODS In this prospective clinical study, aortic 4D flow MRI was performed at the Kuopio University Hospital on 30 patients diagnosed with AA dilatation (maximum diameter >40 mm) between August 2017 and July 2020. The MRI was repeated after a 1-year follow-up, with AA dimensions and 4D flow parameters analysed retrospectively at both time points. The standard error of measurement was used to assess the statistical significance of the growth rate of AA dilatation. Flow displacement (FD) was transformed to a class-scaled parameter using FD ≥5% as a threshold. RESULTS Statistically significant growth [median 2.1 mm (1.5–2.2 mm); P = 0.03] was detected in 6 male patients (20%); the AA diameter remained unchanged [0.2 mm (−0.3 to 0.9 mm)] in 24 patients (80%). An increased FD at the baseline was associated with significant growth during the 1-year follow-up in the proximal AA. An association was detected between decreased total wall shear stress and significant aortic growth in the inner curve of the sinotubular junction [529 mPa (449–664 mPa) vs 775 mPa (609–944 mPa); P = 0.03] and the anterior side of the proximal aortic arch [356 mPa (305–367 mPa) vs 493 mPa (390–586 mPa); P Dilatation of the ascending aorta (AA) often develops without any clinically significant symptoms, making it difficult to detect. |
Databáze: | OpenAIRE |
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