Antibacterial activity and QSAR of homoisoflavanones isolated from six Hyacinthaceae species
| Autor: | Dulcie A. Mulholland, J. Van Staden, E.E. Elgorashi, Sarel F. Malan, K. Du Toit, Siegfried E. Drewes |
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| Rok vydání: | 2007 |
| Předmět: |
Drimiopsis burkei
Quantitative structure–activity relationship Traditional medicine Albuca Plant Science Biology Quantitative structure–activity relationships biology.organism_classification Eucomis Toxicology Physicochemical descriptors Eucomis comosa Drimiopsis maculata Homoisoflavanones Hyacinthaceae Multiple linear regression analysis Antibacterial activity |
| Zdroj: | South African Journal of Botany. 73(2):236-241 |
| ISSN: | 0254-6299 |
| DOI: | 10.1016/j.sajb.2007.01.002 |
| Popis: | Antibacterial activity, as detected in the bioautographic and microplate assays against Staphylococcus aureus, was shown for thirteen homoisoflavanones isolated from six Hyacinthaceae species. Four of these homoisoflavanones were isolated from Eucomis comosa, one from Eucomis schijffii, one from Albuca fastigiata, one from Drimia delagoensis, five from Drimiopsis maculata and one from Drimiopsis burkei. Extracts from most of these plants are employed as traditional medicines in South Africa. Biological screening was followed by a computer-based quantitative structure–activity relationship (QSAR) study. Stepwise multiple linear regression analysis of the data yielded a statistically significant two-component model (R2=0.81, p |
| Databáze: | OpenAIRE |
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