Prevention of the stress-induced increase in frontal cortical dopamine efflux of freely moving rats by long-term treatment with antidepressant drugs
| Autor: | J. David Jentsch, M.Giuseppina Pisu, Mariangela Serra, Francesca Spiga, Giovanni Biggio, Laura Dazzi |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Imipramine Neuroactive steroid medicine.drug_class Dopamine Microdialysis Mirtazapine Mianserin Antidepressive Agents Tricyclic Pharmacology Anxiolytic Rats Sprague-Dawley medicine Animals Pharmacology (medical) Progesterone Biological Psychiatry Electroshock business.industry Dopaminergic Antidepressive Agents Frontal Lobe Rats Psychiatry and Mental health Neurology Anxiogenic Pregnenolone Antidepressant Steroids Neurology (clinical) Extracellular Space business Selective Serotonin Reuptake Inhibitors Stress Psychological medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 11:343-349 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/s0924-977x(01)00105-5 |
| Popis: | Use of antidepressant drugs in the treatment of anxiety disorders has recently increased due to the anxiolytic effect of some of these agents. Because dopaminergic transmission in the prefrontal cortex is sensitive to anxiogenic or stressful stimuli, the effects of two antidepressant drugs with different mechanisms of action, imipramine and mirtazapine, on the response of rat cortical dopaminergic neurons to stress were investigated. A 2-week (but not single dose) administration of imipramine (10 mg/kg, i.p., twice daily) or mirtazapine (10 mg/kg, i.p., once daily) reduced and completely antagonized, respectively, the increase in dopamine release in the prefrontal cortex elicited by footshock stress. Long-term administration of imipramine or mirtazapine had no marked effect on the stress-induced increases in the brain or plasma concentrations of neuroactive steroids or corticosterone. An attenuation of the response of mesocortical dopaminergic neurons to stress induced by long-term treatment with antidepressants might contribute to the anxiolytic effects of such drugs. |
| Databáze: | OpenAIRE |
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