Adiponectin is associated with insulin sensitivity in white European men but not black African men
| Autor: | Oluwatoyosi Bello, Fariba Shojaee-Moradie, Nicola Jackson, Stephanie A. Amiel, Louise M Goff, Olah Hakim, Geoffrey Charles-Edwards, A. Margot Umpleby, Janet L. Peacock, Meera Ladwa |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Black People Adipokine Adipose tissue 030209 endocrinology & metabolism Inflammation Type 2 diabetes White People Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Internal Medicine Humans Medicine 030212 general & internal medicine Aged Adiponectin business.industry Incidence Leptin Insulin Middle Aged medicine.disease United Kingdom Diabetes Mellitus Type 2 Female Resistin Insulin Resistance medicine.symptom business Biomarkers |
| Zdroj: | Diabetic Medicine. 38 |
| ISSN: | 1464-5491 0742-3071 |
| Popis: | AIMS We aimed to assess ethnic differences in inflammatory markers and their relationships with insulin sensitivity and regional adiposity between white European and black African men. METHODS A total of 53 white European and 53 black African men underwent assessment of inflammatory markers alongside Dixon-magnetic resonance imaging to quantify subcutaneous and visceral adipose tissue and intrahepatic lipid. A hyperinsulinaemic-euglycaemic clamp was used to measure whole-body and adipose tissue insulin sensitivity. To assess ethnic differences in relationships, the statistical significance of an interaction term between adipokines and ethnic group was tested in multivariable regression models. RESULTS The black African men exhibited significantly lower adiponectin and tumour necrosis factor-α (TNF-α) and greater interleukin-10 (IL-10) compared to white European men (all p |
| Databáze: | OpenAIRE |
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