Varying features of early age-of-onset 'Sporadic' and hereditary nonpolyposis colorectal cancer patients
| Autor: | Christina Cellini, Philip B. Paty, Alfred M. Cohen, Jose G. Guillem, Stuart H. Q. Quan, W. Douglas Wong, Melissa Murray, Jeremy Ng, Melissa Fazzari, Jorge Puig La Calle |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Oncology Amsterdam criteria medicine.medical_specialty Adolescent Family Cancer History Colorectal cancer Gastroenterology Diagnosis Differential Surgical oncology Internal medicine medicine Humans Family Age of Onset Family history business.industry Cancer Neoplasms Second Primary General Medicine Middle Aged Prognosis medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Colorectal surgery Survival Rate Female Age of onset Colorectal Neoplasms business |
| Zdroj: | Diseases of the Colon & Rectum. 42:36-42 |
| ISSN: | 0012-3706 |
| Popis: | PURPOSE: Although the criteria for clinical diagnosis of hereditary nonpolyposis colorectal cancer are not fully agreed on, young age seems to be a common trait. The purpose of this study is to identify clinicopathologic features of hereditary nonpolyposis colorectal cancer in early age-of-onset colorectal cancer patients stratified as a function of family cancer history. METHODS: Two hundred thirty consecutive colorectal cancer patients 40 years or older at time of diagnosis were registered into an ongoing database during a ten-year period. Accurate family history was obtainedvia medical records, telephone calls, and questionnaires on 146 patients. According to extent of family history of cancer, patients were stratified into seven groups: 1) fulfilling Amsterdam criteria, 2) fulfilling less strict criteria, 3) having at least one first-degree relative with colorectal cancer, 4) having at least one distant relative with colorectal cancer, 5) having at least one first-degree relative with any cancer, 6) having at least one distant relative with any cancer, 7) having no family history of cancer. RESULTS: Twenty-two of 146 patients fulfilled Amsterdam and less strict hereditary nonpolyposis colorectal cancer criteria (15 percent). These hereditary nonpolyposis colorectal cancer patients were significantly younger (31vs. 35 years;P=0.0003) and had more metachronous colorectal cancer (27 percentvs. 2 percent;P=0.007) and less colorectal cancer with nodal or metastatic spread than the non-hereditary nonpolyposis colorectal cancer patients (35 percentvs. 65 percent;P=0.01). CONCLUSION: Precise familial cancer assessment in early age-of-onset colorectal cancer increases the yield of hereditary nonpolyposis colorectal cancer diagnosis. Because of the frequent development of metachronous colorectal cancer and favorable prognosis, extensive rather than segmental surgery should be considered in early age-of-onset colorectal cancer patients belonging to hereditary nonpolyposis colorectal cancer families. |
| Databáze: | OpenAIRE |
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