Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss
| Autor: | Peter A. Boxer, Colleen G. Le Prell, David C. Bennett, David F. Dolan |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Hearing loss medicine.medical_treatment Guinea Pigs Physiology Ascorbic Acid Audiology Antioxidants Article Pharmacokinetics Physiology (medical) otorhinolaryngologic diseases Medicine Animals Vitamin E Magnesium Saline business.industry Biochemistry (medical) Public Health Environmental and Occupational Health General Medicine medicine.disease Ascorbic acid beta Carotene Hearing Loss Noise-Induced Dietary Supplements Analysis of variance medicine.symptom business Auditory fatigue Noise-induced hearing loss |
| Zdroj: | Translational research : the journal of laboratory and clinical medicine. 158(1) |
| ISSN: | 1878-1810 |
| Popis: | Hearing loss encompasses both temporary and permanent deficits. If temporary threshold shift (TTS) and permanent threshold shift (PTS) share common pathological mechanisms, then agents that reduce PTS should also reduce TTS. Several antioxidant agents have reduced PTS in rodent models; however, reductions in TTS have been inconsistent. This study first determined whether dietary antioxidants (beta-carotene, and vitamins C and E) delivered in combination with magnesium (Mg) reliably increase plasma concentrations of the active agents. Then, additional manipulations tested the hypothesis that these nutrients reduce acute TTS insult in the first 24 hours following loud sound, as well as longer lasting changes in hearing measured up to 7 days post-noise. Saline or nutrients were administered to guinea pigs prior to and after noise exposure. Sound-evoked electrophysiological responses were measured before noise, with tests repeated 1-hour post-noise, as well as 1-, 3-, 5-, and 7-days post-noise. All subjects showed significant functional recovery; subjects treated with nutrients recovered more rapidly, and had better hearing outcomes at early post-noise times as well as the final test time. Thus, this combination of nutrients, which produced significant increases in plasma concentrations of vitamins C and E and Mg, effectively reduced hearing loss at multiple post-noise times. These data suggest free radical formation contributes to TTS as well as PTS insults, and suggest a potential opportunity to prevent TTS in human populations. |
| Databáze: | OpenAIRE |
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