Cognitive deficits in progressive supranuclear palsy, Parkinson's disease, and multiple system atrophy in tests sensitive to frontal lobe dysfunction

Autor: Klaus W. Lange, Trevor W. Robbins, M. James, A. J. Lees, Peter Leigh, C. D. Marsden, B. A. Summers, Adrian M. Owen, Niall Quinn
Rok vydání: 1994
Předmět:
Male
medicine.medical_specialty
Time Factors
Parkinson's disease
Cognition Disorders/physiopathology
Neuropsychological Tests
Audiology
Neuropsychiatry
Spatial memory
Memory Disorders/physiopathology
Progressive supranuclear palsy
Thinking
03 medical and health sciences
0302 clinical medicine
Atrophy
Task Performance and Analysis
medicine
Humans
Attention
Parkinson Disease/physiopathology
Aged
Memory Disorders
Palsy
Frontal Lobe/physiopathology
Parkinson Disease
Middle Aged
medicine.disease
Supranuclear Palsy
Progressive/physiopathology
Frontal Lobe
030227 psychiatry
Cognitive test
Psychiatry and Mental health
Frontal lobe
Atrophy/physiopathology
150 Psychologie
Space Perception
ddc:150
Female
Surgery
Supranuclear Palsy
Progressive
Neurology (clinical)
Cognition Disorders
Psychology
Neuroscience
030217 neurology & neurosurgery
Research Article
Zdroj: Journal of Neurology, Neurosurgery & Psychiatry. 57:79-88
ISSN: 0022-3050
DOI: 10.1136/jnnp.57.1.79
Popis: Groups of patients with idiopathic Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy or Steele-Richardson-Olszewski syndrome, matched for overall clinical disability, were compared using three computerised cognitive tests previously shown to be sensitive to frontal lobe dysfunction. On a test of planning based on the Tower of London task, all three groups were impaired, but in different ways. The groups with palsy and Parkinson's disease were slower in the measure of initial thinking time, whereas the group with multiple system atrophy was only slower in a measure of thinking time subsequent to the first move, resembling patients with frontal lobe damage. On a test of spatial working memory, each group showed deficits relative to their matched control groups, but the three groups differed in their strategy for dealing with this task. On a test of attentional set shifting, each group was again impaired, mainly at the extradimensional shifting stage, but the group with Steele-Richardson-Olszewski syndrome exhibited the greatest deficit. The results are compared with previous findings in patients with Alzheimer's disease or frontal lobe damage. It is concluded that these basal ganglia disorders share a distinctive pattern of cognitive deficits on tests of frontal lobe dysfunction, but there are differences in the exact nature of the impairments, in comparison not only with frontal lobe damage but also with one another.
Databáze: OpenAIRE
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