Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men
| Autor: | Kaoru Moriyama, Taiji Tsukamoto, Yoshie Nagata, Akio Takayanagi, Tetsuji Miura, Fumimasa Fukuta, Hirokazu Tsuji, Hiroshi Akasaka, Hideyuki Akaza, Shigeyuki Saito, Yukiko Sugiyama, Hirofumi Ohnishi, Naoya Masumori, Mitsuru Mori |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Epidemiology Physiology Genistein Feces chemistry.chemical_compound Prostate cancer Internal medicine Slackia medicine Humans Intestinal Mucosa Aged biology Daidzein Public Health Environmental and Occupational Health Prostatic Neoplasms food and beverages Equol Glycitein Middle Aged Isoflavones Prognosis medicine.disease biology.organism_classification Actinobacteria Intestines Endocrinology Oncology chemistry Case-Control Studies Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:2693-2697 |
| ISSN: | 1513-7368 |
| Popis: | Background: Isoflavones, which are included in soybeans, have been suggested to protect against prostate cancer. Equol, one of isoflavones, is an intestinally derived bacterial metabolite of daidzein. A newly identified equol-producing bacterium, Slackia sp. strain NATTS, with a high equol-producing activity was isolated from human feces in Japanese adults. Counts of Slackia sp. strain NATTS in intestinal flora have not been assessed with regard to prostate cancer risk. In this study, we investigated the association of serum isoflavones and counts of Slackia sp. strain NATTS with prostate cancer risk in a case-control study. Materials and Methods: Concentrations of isoflavones and counts of Slackia sp. strain NATTS in feces were measured from 44 patients with prostate cancer and 28 hospital controls. The risk of prostate cancer was evaluated in terms of odds ratios (ORs) and 95% confidence intervals (CIs) by the logistic regression analysis. Results: The detection proportions of Slackia sp. strain NATTS in cases and controls were 34.1% and 25.0%, respectively. Counts of Slackia sp. strain NATTS were significantly correlated with serum concentrations of equol both in cases and controls (Spearman correlation coefficients, r s =0.639 and r s =0.572, p |
| Databáze: | OpenAIRE |
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