Mitochondrial efficiency and exercise economy following heat stress: a potential role of uncoupling protein 3
| Autor: | Roger A. Vaughan, Nicholas P. Gannon, D L. Parker, Suzanne M. Schneider, Len Kravitz, Roy M. Salgado, Trisha A. Van Dusseldorp, James J. McCormick, Robert W. Kenefick, Christine M. Mermier, Ailish C. Sheard |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Physiology Acclimatization Mitochondrion Biology Thermoregulation Cell Line 03 medical and health sciences Mice 0302 clinical medicine Oxygen Consumption Heat acclimation In vivo Physiology (medical) Internal medicine medicine Myocyte Uncoupling protein Animals Humans Uncoupling Protein 3 Heat shock Exercise UCP3 Original Research cross‐tolerance Muscle Cells Endurance and Performance Altitude 030229 sport sciences Mitochondria Cross-tolerance exercise capacity 030104 developmental biology Endocrinology Biochemistry heat acclimation Cellular Physiology Heat-Shock Response |
| Zdroj: | Physiological Reports |
| ISSN: | 2051-817X |
| Popis: | Heat stress has been reported to reduce uncoupling proteins (UCP) expression, which in turn should improve mitochondrial efficiency. Such an improvement in efficiency may translate to the systemic level as greater exercise economy. However, neither the heat‐induced improvement in mitochondrial efficiency (due to decrease in UCP), nor its potential to improve economy has been studied. Determine: (i) if heat stress in vitro lowers UCP3 thereby improving mitochondrial efficiency in C2C12 myocytes; (ii) whether heat acclimation (HA) in vivo improves exercise economy in trained individuals; and (iii) the potential improved economy during exercise at altitude. In vitro, myocytes were heat stressed for 24 h (40°C), followed by measurements of UCP3, mitochondrial uncoupling, and efficiency. In vivo, eight trained males completed: (i) pre‐HA testing; (ii) 10 days of HA (40°C, 20% RH); and (iii) post‐HA testing. Pre‐ and posttesting consisted of maximal exercise test and submaximal exercise at two intensities to assess exercise economy at 1600 m (Albuquerque, NM) and 4350 m. Heat‐stressed myocytes displayed significantly reduced UCP3 mRNA expression and, mitochondrial uncoupling (77.1 ± 1.2%, P |
| Databáze: | OpenAIRE |
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