Nucleobase-involved native chemical ligation: a novel reaction between an oxanine nucleobase and N-terminal cysteine for oligonucleotide–peptide conjugation

Autor:	Yohei Koike, Kunihiko Tajima, Yuko Ide, Kenji Kanaori, Eui Kyoung Jang, Seung Pil Pack
Rok vydání:	2020
Předmět:	Stereochemistry Oligonucleotides Peptide 010402 general chemistry 01 natural sciences Catalysis Nucleobase 03 medical and health sciences Materials Chemistry Cysteine 030304 developmental biology chemistry.chemical_classification 0303 health sciences Bioconjugation Molecular Structure Chemistry Oligonucleotide Metals and Alloys Purine Nucleosides General Chemistry Native chemical ligation 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Amino acid Ceramics and Composites Peptides
Zdroj:	Chemical Communications. 56:5508-5511
ISSN:	1364-548X 1359-7345
DOI:	10.1039/c9cc08808c
Popis:	In bioconjugation chemistry, achieving a target-specific reaction for a non-modified amino acid is challenging. Here, we report a novel nucleobase-involved native chemical ligation (NbCL) that allows a site-specific oligonucleotide-peptide conjugation via a new S-N acyl transfer reaction between an oxanine nucleobase and N-terminal cysteine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca245e85e565318ebe54d793c832868 https://doi.org/10.1039/c9cc08808c Zobrazit plný text záznamu