Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival
| Autor: | Sudeshna Bandyopadhyay, Mingxin Che, Veronica L. Schimp, Robert T. Morris, Rouba Ali-Fehmi, John M. Malone, Adnan R. Munkarah |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Vascular Endothelial Growth Factor A
Pathology medicine.medical_specialty Serous carcinoma Angiogenesis Antigens CD34 Apoptosis Tumor M2-PK Ovarian tumor Ovarian carcinoma Biomarkers Tumor medicine Humans Cell Proliferation Ovarian Neoplasms Neovascularization Pathologic business.industry Membrane Proteins Obstetrics and Gynecology medicine.disease Immunohistochemistry Cystadenocarcinoma Serous Serous fluid Vascular endothelial growth factor A Ki-67 Antigen Proto-Oncogene Proteins c-bcl-2 Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Tumor progression Disease Progression Female business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 192:819-825 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/j.ajog.2004.10.587 |
| Popis: | Cyclo-oxygenase-2 seems to be involved at various steps in the processes of tumor progression. The objective of this study was to examine the relationship between cyclo-oxygenase-2 expression and tumor proliferation, apoptosis and angiogenesis in patients with advanced stage high-grade ovarian carcinoma.Specimens from 118 patients with high-grade and advanced stage (III, IV) serous ovarian carcinoma were evaluated by immunohistochemistry for cyclo-oxygenase-2, Ki-67, vascular endothelial growth factor, and bcl-2 expression. Tumor microvessel density was assessed with CD34 immunostaining. We investigated the relationships between cyclo-oxygenase-2 expression and clinicopathologic characteristics, tumor angiogenesis (tumor microvessel density and vascular endothelial growth factor expression), and tumor proliferation and apoptosis. The effect of cyclooxygenase-2 expression on patient survival was determined.There was a significant positive correlation between cyclo-oxygenase-2 expression in tumor cells and markers of tumor proliferation and angiogenesis. In univariate survival analysis, high cyclo-oxygenase-2 and high Ki-67 expression showed a significant impact of on patient survival (P.001). In multivariate regression analysis, only Ki-67 expression retained its significance as an independent poor prognostic factor (death hazard ratio, 2.0; 95% CI, 1.2-3.3; P.001).Expression of cyclo-oxygenase-2 correlates with tumor proliferation and tumor angiogenesis but not with apoptotic markers (bcl-2 expression) in high-grade, advanced-stage serous ovarian carcinoma. |
| Databáze: | OpenAIRE |
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