Epicardial fat thickness significantly decreases after short-term growth hormone (GH) replacement therapy in adults with GH deficiency
| Autor: | Paolo Beck-Peccoz, Elena Passeri, Sabrina Corbetta, Bruno Ambrosi, Emanuele Ferrante, Andrea Lania, Calin Coman, S. Briganti, Gianluca Iacobellis, Claudia Giavoli, Anna Spada, Eriselda Profka, C.L. Ronchi, Silvia Bergamaschi, F. Ermetici, A.E. Malavazos |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Hormone Replacement Therapy Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Short term growth Intra-Abdominal Fat Body fat percentage Growth hormone deficiency Body Mass Index Internal medicine medicine Humans Obesity Insulin-Like Growth Factor I Dwarfism Pituitary Adiposity Nutrition and Dietetics business.industry Human Growth Hormone Anthropometry Middle Aged medicine.disease Epicardial fat Endocrinology Echocardiography Quality of Life Female Gh replacement Cardiology and Cardiovascular Medicine business Pericardium GH Deficiency Hormone |
| Zdroj: | Nutrition, metabolism, and cardiovascular diseases : NMCD. 23(5) |
| ISSN: | 1590-3729 |
| Popis: | Growth Hormone Deficiency (GHD) is characterized by increased visceral fat accumulation. Echocardiographic epicardial fat thickness is a new marker of visceral adiposity. Aim of the present study was to evaluate whether epicardial fat thickness can significantly change and therefore serve as a marker of visceral fat reduction after short-term rhGH replacement therapy in patients with adult-onset GHD.Echocardiographic epicardial fat thickness was measured in 18 patients (10 M, 8 F, age 48 ± 11.8 yrs, BMI 29 ± 5.9 kg/m(2)) with adult-onset GHD, at baseline and after 6 and 12 months of rhGH therapy and in 18 healthy matched controls, at baseline. Echocardiographic epicardial fat thickness, conventional anthropometric and metabolic parameters, body fat percentage and quality of life were also evaluated. Epicardial fat thickness in adult GHD patients was higher than in controls (9.8 ± 2.8 vs 8 ± 3 mm, p 0.05). Epicardial fat thickness significantly decreased after 6-months of rhGH replacement therapy (from 9.8 ± 2.8 to 7.0 ± 2.3 mm, P 0.01, i.e. -29% from baseline). After 12 months of rhGH replacement therapy, epicardial fat thickness showed a further significant decrease (from 7.0 ± 2.3 to 5.9 ± 3.1 mm, P 0.01, i.e. -40% from baseline). No significant changes in BMI or waist circumference after 6 or 12 months of rhGH therapy were observed.Echocardiographic epicardial fat thickness may represent a valuable and easy marker of visceral fat and visceral fat changes during rhGH replacement treatment in patients with adult-onset growth hormone deficiency. |
| Databáze: | OpenAIRE |
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