Activation of protein mediators of inflammation and evidence for endotoxemia in Borrelia recurrentis infection
| Autor: | Robert E. Galloway, George H. Goldsmith, Thomas Butler, Hidehiko Saito, Jack Levin, Sissay Awoke, Craig K. Wallace, George B. Naff |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Adolescent media_common.quotation_subject Humans Medicine Antigens Child Limulus Test Blood coagulation test media_common Factor XII Properdin biology business.industry Convalescence Prekallikrein Relapsing Fever Fibrinogen Complement System Proteins General Medicine Middle Aged biology.organism_classification Blood proteins Complement system Endotoxins Doxycycline Immunology Female Blood Coagulation Tests Borrelia recurrentis business |
| Zdroj: | The American Journal of Medicine. 63:933-938 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(77)90548-4 |
| Popis: | Fifteen patients with Borrelia recurrentis infection were studied to evaluate the role of certain plasma proteins and endotoxin in the pathophysiology of both the acute illness and the Jarisch-Herxheimer-like reaction. The causative spirochetes disappeared from the blood during the Jarisch-Herxheimer-like reaction, which occurred about 2 hours after antibiotic therapy. The mean titers of Hageman factor, plasma prekallikrein and serum hemolytic complement activity were decreased at the time of admission and 2 hours after treatment, and rose to normal values during convalescence. Serum properdin titers were decreased in 14 patients at the time of admission, in 12 patients 2 hours after treatment, and in none during convalescence. The frequency of elevated levels of fibrinogen-related antigens increased from three patients at the time of admission to 12 patients 2 hours after treatment. Results of plasma limulus tests for endotoxin-like material were positive in 11 patients at the time of admission and in 13 patients 2 hours after treatment. These findings demonstrated that Hageman factor, prekallikrein and proteins of the complement system are activated in B. recurrentis infection and that endotoxin may play a role in both the acute illness and in the development of the Jarisch-Herxheimer-like reaction after treatment. |
| Databáze: | OpenAIRE |
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