Transforming growth factor β type II receptor as a marker in diffuse large B cell lymphoma
| Autor: | Jieping Jin, Shudan Mao, Wenqi Yang, Limei Ai, Zhe Li |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty 5 year survival rate Biology Protein Serine-Threonine Kinases chemistry.chemical_compound Transforming Growth Factor beta Lactate dehydrogenase medicine Biomarkers Tumor Humans In patient Stage (cooking) Receptor Aged Receptor Transforming Growth Factor-beta Type II General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Survival Analysis chemistry Cancer research Female Lymphoma Large B-Cell Diffuse Diffuse large B-cell lymphoma Receptors Transforming Growth Factor beta Transforming growth factor Signal Transduction |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(12) |
| ISSN: | 1423-0380 |
| Popis: | The objective of this study was to investigate the expression and significance of the transforming growth factor β type II receptor (TGFβRII) in diffuse large B cell lymphoma. All patients were enrolled at the First Affiliated Hospital of Liaoning Medical University between 2001 and 2007. The median follow-up period was 53.3 months. Of the 338 patients studied, 131 (38.76 %) had TGFβRII positive expression on immunohistochemistry. The 5 year survival rate was significantly higher in patients with TGFβRII expression than in those without TGFβRII expression (40.3 vs. 31.6 %, P = 0.041). Multivariate analysis identified TGFβRII expression as an independent predictive parameter for survival, in addition to lactate dehydrogenase, clinical stage, and histologic subtype. TGFβRII expression may be considered a new prognostic factor of diffuse large B cell lymphoma. |
| Databáze: | OpenAIRE |
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