SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients
| Autor: | Liping Yang, Hai-Qin Feng, Hong Wu, Cai-Ru Liu, Jun-de Hou, Jian-Cai Ma |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Oncology medicine.medical_specialty cervical cancer Observational Study Uterine Cervical Neoplasms Cervix Uteri SIRT2 survival Disease-Free Survival 03 medical and health sciences Sirtuin 2 0302 clinical medicine Internal medicine Biomarkers Tumor Humans Medicine 030212 general & internal medicine Stage (cooking) clinical characteristics Survival analysis Proportional Hazards Models Retrospective Studies Cervical cancer business.industry Proportional hazards model Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Survival Analysis 030220 oncology & carcinogenesis Biomarker (medicine) Immunohistochemistry Female tumor tissue business Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | This study aimed to compare the sirtuin 2 (SIRT2) expression between tumor tissue and adjacent tissue, and to investigate the association of tumor SIRT2 expression with clinical characteristics and survival profiles in cervical cancer patients. One hundred ninety-one cervical cancer patients were reviewed in this retrospective study. All patients underwent surgical resection and had well-preserved tumor tissue and adjacent tissue, which were obtained for SIRT2 expression detection by immunohistochemistry (IHC). Clinical parameters were obtained. Disease free survival (DFS) and overall survival (OS) were calculated. Both SIRT2 expression by IHC score (P 3) (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|