Changes in white matter and the effects of fluoxetine on such changes in the CUS rat model of depression
| Autor: | Yuan Gao, Yao Yao, Xin Liang, Jing Tang, Jing Ma, Ying-qiang Qi, Chun-xia Huang, Yang Zhang, Lin-mu Chen, Feng-lei Chao, Lei Zhang, Yan-min Luo, Qian Xiao, Lian Du, San-rong Wang, Yong Tang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Rat model Stereology Nerve Fibers Myelinated White matter Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine Fluoxetine medicine Animals Depression (differential diagnoses) Myelin Sheath Chemistry Depression General Neuroscience White Matter Sprague dawley Disease Models Animal 030104 developmental biology Endocrinology medicine.anatomical_structure Myelin sheath Antidepressant Antidepressive Agents Second-Generation 030217 neurology & neurosurgery Selective Serotonin Reuptake Inhibitors Stress Psychological medicine.drug |
| Zdroj: | Neuroscience letters. 694 |
| ISSN: | 1872-7972 |
| Popis: | Objective To explore the pathogenesis of depression and the possible mechanism of the effects of selective serotonin reuptake inhibitors (SSRIs) on the myelinated fibers and myelin sheaths in the white matter during the antidepressant action of fluoxetine. Methods In this study, Sprague Dawley (SD) rats were divided into a Control group, a group treated with CUS and no drugs (CUS/Standard group) and a group treated with CUS and fluoxetine (CUS/FLX group). The CUS/FLX group was treated with fluoxetine at dose of 5 mg/kg for 21 days. The white matter volume, the myelinated fiber parameters and the myelin sheath volume in the white matter were calculated from transmission electron microscope images through unbiased stereological methods. Results The total volume and total length of myelinated fibers;and mean volume of white matter of the CUS/Standard group were significantly decreased compared to values from the control group (p = 0.025, p = 0.007, p = 0.000), whereas no significant differences in these stereological parameters were found between the CUS/Standard and CUS/FLX groups (p > 0.05). Conclusions Fluoxetine successfully treated depression-like behavior but had no effects on the white matter or its component myelinated fibers in the CUS rat model of depression. |
| Databáze: | OpenAIRE |
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