Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy
| Autor: | Milka Mavija, Faruk Nisic, Adem Cemerlic, Orhan Lepara, Aida Nisic, Nina Jovanovic, Emina Alimanovic-Halilovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pars plana
medicine.medical_specialty genetic structures medicine.medical_treatment Eye disease Vitrectomy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Clinical Research Ophthalmology medicine postoperative complications 030212 general & internal medicine Rubeosis iridis pars plana vitrectomy vascular endothelial growth factor business.industry Diathermy General Medicine medicine.disease Intraoperative Hemorrhage eye diseases Vascular endothelial growth factor medicine.anatomical_structure chemistry Vitreous hemorrhage Medicine biomarker sense organs business proliferative diabetic retinopathy |
| Zdroj: | Archives of Medical Science : AMS Archives of Medical Science, Vol 15, Iss 2, Pp 449-456 (2019) |
| ISSN: | 1896-9151 1734-1922 |
| Popis: | Introduction The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV). Material and methods Ninety subjects were surgically treated with PPV and followed up for 12 months at the Clinical Centre University Sarajevo, Clinic for Eye Disease. Exclusion criteria were presence of other eye diseases, systemic acute/chronic inflammatory conditions, or malignant neoplasms; previously performed PPV surgery; previously received intravitreal or systemic anti-VEGF therapy. A vitreous sample was obtained while performing the PPV procedure, using the Quantikine ELISA test to determine VEGF level, as a risk factor. Outcome measures were intraoperative and postoperative complications reported using categorical data: blunt and sharp dissection of membranes, intraoperative hemorrhage stopped by increasing infusion pressure, pressing with blunt instrument, or using diathermy. The following postoperative complications were assessed on the first day and at the 12-month follow-up visit: vitreous hemorrhage, fibrovascular proliferation (FVP), rubeosis iridis, and neovascular glaucoma (NVG). Results Levels of vitreous VEGF at the time of PPV were significantly higher in eyes with: vitreous hemorrhage on the first day after PPV (p = 0.003); FVP on the first day and 12 months after PPV (p = 0.002 and p < 0.001, respectively); iris rubeosis on the first day and 12 months after PPV surgery (p < 0.001, and p = 0.001, respectively); NVG on the first day and 12 months after PPV surgery (p = 0.043 and p = 0.011, respectively), compared to the eyes without complications. Conclusions Preoperative levels of VEGF in vitreous can be a useful biomarker and predictor of the postoperative outcome in terms of intraoperative and postoperative complications. |
| Databáze: | OpenAIRE |
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