Interethnic differences in the relevance of CYP2C9 genotype and environmental factors for diclofenac metabolism in Hispanics from Cuba and Spain

Autor:	Mercedes Alvarez, Idilio González, Luis R Calzadilla, Pedro Dorado, Bárbaro Pérez, J. Cobaleda, Eva M Peñas-Lledó, Adrián LLerena
Rok vydání:	2013
Předmět:	Pharmacology Diclofenac Polymorphism Genetic Genotype business.industry Anti-Inflammatory Agents Non-Steroidal Cuba Urine Metabolism stomatognathic diseases Spain Healthy volunteers Genetics Ethnicity Molecular Medicine Medicine Humans business CYP2C9 medicine.drug Cytochrome P-450 CYP2C9
Zdroj:	The pharmacogenomics journal. 14(3)
ISSN:	1473-1150
Popis:	The aims of this study were to evaluate the diclofenac metabolism in Hispanics from Cuba and Spain and its relation to ethnicity, CYP2C9 genotypes and environmental factors. Diclofenac hydroxylation capacity (concentration ratios of diclofenac/metabolites in 8-h urine) was studied in 160 Cuban (classified as 76 Cuban-Whites—CWs and 84 Cuban-Mestizos—CMs) and 148 Spaniard (SPs) healthy volunteers. Diclofenac and its main metabolites, 4′-hydroxy (OH), 3′-OH and 5-OH diclofenac, and CYP2C9*2 to *6 and *8 alleles were also determined in 132 and 128 CWs and CMs, respectively. Gender, tobacco, caffeine and ethanol consumption were also evaluated. The mean diclofenac/4′-OH diclofenac ratio was higher in CMs (0.72±0.25) than in CWs (0.64±0.20; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc969036954bd7cec77c51280143c511 https://pubmed.ncbi.nlm.nih.gov/23959274 Zobrazit plný text záznamu