Status of selected nutrients and progression of human immunodeficiency virus type 1 infection
| Autor: | H. Baker, Donald B. Louria, John D. Bogden, Shenggao Han, Wenjie Li, George Perez, James M. Oleske, Francis W. Kemp, Thomas N. Denny, K.S. Bruening, Joan Lloyd, Joan Skurnick, Patricia Kloser |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Alcohol Drinking Anti-HIV Agents Medicine (miscellaneous) Physiology HIV Infections Disease Biology Hematocrit chemistry.chemical_compound Immune system T-Lymphocyte Count Reference Values Immunopathology medicine Choline Humans Nutritional Physiological Phenomena Nutrition and Dietetics medicine.diagnostic_test Middle Aged CD4 Lymphocyte Count Cross-Sectional Studies chemistry Blood chemistry Immunology Disease Progression HIV-1 Female Viral disease |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 0002-9165 |
| Popis: | Background: Immune function is highly dependent on nutritional status because the large mass and high rate of cellular turnover of the immune system make it a major user of nutrients. Furthermore, nutrient requirements may be increased during acute and chronic infections, including HIV-1 infection. Objective: The current study was designed to assess relations among HIV-1 progression and 11 nutritional and demographic variables. Design: The participants were 106 HIV-infected outpatients and 29 uninfected control subjects (n = 89 men and 46 women; age range: 35-57 y). The HIV-infected subjects represented a broad range of disease progression. Results: We found lower concentrations of plasma and erythrocyte magnesium and of erythrocyte reduced glutathione beginning early in the course of HIV-1 infection. Significantly decreased hematocrit and increased serum copper concentration developed only late in the course of the disease. Statistically significant univariate associations were found between the CD4 + T lymphocyte count and hematocrit, plasma magnesium concentration, and plasma zinc concentration. The lowest erythrocyte magnesium concentrations occurred in HIV-infected subjects who consumed alcoholic beverages. Independent variables that were significant joint predictors of CD4 + cell count in multiple regression analyses were hematocrit and plasma free choline and zinc concentrations. These 3 factors together explained 43% of the variability in CD4 + cell counts. Conclusion: The results provide evidence that compromised nutritional and antioxidant status begin early in the course of HIV-1 infection and may contribute to disease progression. |
| Databáze: | OpenAIRE |
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