Development of an Experimental Model to Study the Relationship Between Day-to-Day Variability in Blood Pressure and Aortic Stiffness
| Autor: | Vincent Molinie, Michel E. Safar, Hubert Dabiré, Yvonnick Bézie, Camille Bouissou-Schurtz, Véronique Regnault, Sophie Renet, Georges Lindesay |
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| Přispěvatelé: | Biomécanique cellulaire et respiratoire (BCR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Internationales Servier [Suresnes] (IRIS), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Groupe hospitalier Paris Saint-Joseph - Hôpital, Centre de diagnostic, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôtel-Dieu-Université Paris Descartes - Paris 5 (UPD5), Service d'anatomopathologie [Fort de France, Martinique], CHU Fort de France, Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Université Paris Descartes - Paris 5 (UPD5) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
systolic blood pressure aortic stiffness Physiology pulse wave velocity Placebo lcsh:Physiology [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system fibronectin Physiology (medical) Internal medicine Medicine Receptor Pulse wave velocity Original Research Spontaneously Hypertensive Rat (SHR) biology lcsh:QP1-981 business.industry telemetry diastolic blood pressure medicine.disease long-term blood pressure variability Endocrinology Blood pressure Valsartan biology.protein Arterial stiffness cardiovascular system Aortic stiffness blood pressure variability business spontaneously hypertensive rats Elastin medicine.drug |
| Zdroj: | Frontiers in Physiology Frontiers in Physiology, Frontiers, 2015, 6, pp.368. ⟨10.3389/fphys.2015.00368⟩ Frontiers in Physiology, Vol 6 (2015) |
| ISSN: | 1664-042X |
| Popis: | We aimed to develop an animal model of long-term blood pressure variability (BPV) and to investigate its consequences on aortic damage. We hypothesized that day-to-day BPV produced by discontinuous treatment of spontaneously hypertensive rats (SHR) by valsartan may increase arterial stiffness. For that purpose, rats were discontinuously treated, 2 days a week, or continuously treated by valsartan (30 mg/kg/d in chow) or placebo. Telemetered BP was recorded during 2 minutes every 15 min, 3 days a week during 8 weeks to cover the full BP variations in response to the treatment schedule. Pulse wave velocity (PWV) and aortic structure evaluated by immunohistochemistry were investigated in a second set of rats treated under the same conditions. Continuous treatment with valsartan reduced systolic BP (SBP) and reversed the aortic structural alterations observed in placebo treated SHR (decrease of medial cross-sectional area). Discontinuous treatment with valsartan decreased SBP to a similar extent but increased the day-to-day blood pressure variability, short term BPV, diastolic blood pressure (DBP) and PWV as compared with continuous treatment. Despite no modifications in the elastin/collagen ratio and aortic thickness, an increase in PWV was observed following discontinuous treatment and was associated with a specific accumulation of fibronectin and its av-integrin receptor compared with both groups of rats. Taken together the present results indicate that a discontinuous treatment with valsartan is able to induce a significant increase in day-to-day blood pressure variability coupled to an aortic phenotype close to that observed in hypertension. This experimental model should pave the way for future experimental and clinical studies aimed at assessing how long-term BPV increases aortic stiffness. |
| Databáze: | OpenAIRE |
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