Peculiarities of the circulating phagocytes functional activityin patients with different forms of drug-resistant pulmonary tuberculosis
| Autor: | Bondarenko Bb, Pavlova Mv, El'kin Av, Alekseeva Np, Esmedliaeva Ds, Titarenko Ot, D'iakova Me |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Tuberculosis Phagocyte Neutrophils Drug resistance Neopterin General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Adenosine deaminase Tuberculosis Multidrug-Resistant Humans Medicine Tuberculosis Pulmonary Pathological Pancreatic Elastase biology business.industry Macrophages Elastase Zymosan General Medicine medicine.disease medicine.anatomical_structure chemistry Immunology biology.protein Female business Biomarkers Intracellular |
| Zdroj: | Biomeditsinskaya Khimiya. 58:467-474 |
| ISSN: | 2310-6905 2310-6972 |
| Popis: | Functional activity of circulating phagocytes (macrophages - Ms and neutrophils - Ns) was studied in 30 patients with infiltrative (I) and 30 patients with fibro-cavernous (FC) pulmonary tuberculosis (PT). Difference of the functional activity of both types of cells depending on the PT form was revealed: more significant increase in the oxygen-depending activity in FCPT while bactericide potential estimated with a zymosane induced NST-test was more pronounced in IPT patients. These data correlate with the blood levels of neopterin and elastase, the markers of the M and N activity, respectively. Participation of intracellular ADA in realization of oxygen-depending processes was demonstrated. Results of the multivariant analysis of the whole complex of the studied phagocyte characteristics, reflect their different roles in ther pathological process a prevailing role of Ms in the firstly diagnosed acute tuberculosis process (IPT) and Ns in the chronic progressive process (FCT). |
| Databáze: | OpenAIRE |
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