Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats
| Autor: | Raquel Sirvente, Maria Claudia Irigoyen, Cristiano Mostarda, Leandro E. Souza, Denise Aya Otsuki, Matheus Fachini Vane, Marcelo Luis Abramides Torres, Rubens Campana Pasqualin, José Otávio Costa Auler |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Methyl Ethers Cardiac function curve medicine.medical_specialty Time Factors RD1-811 Myocardial Ischemia Myocardial Infarction Diastole Blood Pressure Myocardial. Rats 030204 cardiovascular system & hematology Autonomic Nervous System Sevoflurane Random Allocation 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Animals Medicine Heart rate variability Myocardial infarction Rats Wistar Pulse Ischemic Preconditioning business.industry medicine.disease Blood pressure Echocardiography Coronary occlusion Anesthesia Anesthetics Inhalation Ischemic Preconditioning Myocardial Models Animal Cardiology Ischemic preconditioning Surgery business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 31, Issue: 5, Pages: 338-345, Published: MAY 2016 Acta Cirurgica Brasileira, Vol 31, Iss 5, Pp 338-345 (2016) Acta Cirúrgica Brasileira v.31 n.5 2016 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE: To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS: Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated. RESULTS: The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS. CONCLUSION: Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in post-acute myocardial infarction period. |
| Databáze: | OpenAIRE |
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