Modulating conscious movement intention by noninvasive brain stimulation and the underlying neural mechanisms
Autor: | Mark Hallett, Zachary H. Douglas, Biyu J. He, Eric M. Wassermann, Brian Maniscalco |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male Consciousness Photic Stimulation medicine.medical_treatment Movement Stimulation Electroencephalography Transcranial Direct Current Stimulation Angular gyrus Young Adult medicine Humans Transcranial direct-current stimulation medicine.diagnostic_test General Neuroscience Motor Cortex Articles Evoked Potentials Motor medicine.anatomical_structure Acoustic Stimulation Brain stimulation Female Primary motor cortex Psychology Neuroscience Psychomotor Performance Motor cortex |
Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(18) |
ISSN: | 1529-2401 |
Popis: | Conscious intention is a fundamental aspect of the human experience. Despite long-standing interest in the basis and implications of intention, its underlying neurobiological mechanisms remain poorly understood. Using high-definition transcranial DC stimulation (tDCS), we observed that enhancing spontaneous neuronal excitability in both the angular gyrus and the primary motor cortex caused the reported time of conscious movement intention to be ∼60–70 ms earlier. Slow brain waves recorded ∼2–3 s before movement onset, as well as hundreds of milliseconds after movement onset, independently correlated with the modulation of conscious intention by brain stimulation. These brain activities together accounted for 81% of interindividual variability in the modulation of movement intention by brain stimulation. A computational model using coupled leaky integrator units with biophysically plausible assumptions about the effect of tDCS captured the effects of stimulation on both neural activity and behavior. These results reveal a temporally extended brain process underlying conscious movement intention that spans seconds around movement commencement. |
Databáze: | OpenAIRE |
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