Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis
| Autor: | Mattie F. Wolf, Chia-shi Wang, Jia Yan, James Bost, Larry A. Greenbaum, Robert Palmer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty Article Subject business.industry 030232 urology & nephrology Patient characteristics Disease Childhood nephrotic syndrome Single Center lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 3. Good health 03 medical and health sciences 0302 clinical medicine Increased risk Nephrology medicine Retrospective analysis 030212 general & internal medicine Outpatient management business Disease complication Research Article |
| Zdroj: | International Journal of Nephrology, Vol 2017 (2017) International Journal of Nephrology |
| ISSN: | 2090-2158 |
| Popis: | There is a paucity of information on outpatient management and risk factors for hospitalization and complications in childhood nephrotic syndrome (NS). We described the management, patient adherence, and inpatient and outpatient usage of 87 pediatric NS patients diagnosed between 2006 and 2012 in the Atlanta Metropolitan Statistical Area. Multivariable analyses were performed to examine the associations between patient characteristics and disease outcome. We found that 51% of the patients were treated with two or more immunosuppressants. Approximately half of the patients were noted to be nonadherent to medications and urine protein monitoring. The majority (71%) of patients were hospitalized at least once, with a median rate of 0.5 hospitalizations per patient year. Mean hospital length of stay was 4.0 (3.8) days. Fourteen percent of patients experienced at least one serious disease complication. Black race, frequently relapsing/steroid-dependent and steroid-resistant disease, and the first year following diagnosis were associated with higher hospitalization rates. The presence of comorbidities was associated with longer hospital length of stay and increased risk of serious disease complications. Our results highlight the high morbidity and burden of NS and point to particular patient subgroups that may be at increased risk for poor outcome. |
| Databáze: | OpenAIRE |
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