Do you know what I'm thinking? Temporal and spatial brain activity during a theory-of-mind task in children with autism
| Autor: | Margot J. Taylor, Charline Urbain, Evdokia Anagnostou, Elizabeth Pang, Daphna Buchsbaum, Veronica Yuk |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Autism Spectrum Disorder Brain activity and meditation Autism ROI region of interest Theory of Mind WASI Wechsler Abbreviated Scale of Intelligence Audiology Executive Function 0302 clinical medicine Theory of mind IFG inferior frontal gyrus TPJ temporoparietal junction Spatial Processing -- physiology MTG middle temporal gyrus Child Children Original Research media_common medicine.diagnostic_test MFG middle frontal gyrus ADOS Autism Diagnostic Observation Schedule TB true belief lcsh:QP351-495 05 social sciences AG angular gyrus Brain Brain -- physiopathology Magnetoencephalography Sciences bio-médicales et agricoles Executive functions MOG middle occipital gyrus Temporal Lobe medicine.anatomical_structure RT response time Feeling Autism spectrum disorder Female FB false belief Psychology ITG inferior temporal gyrus EEG electroencephalography Autism Spectrum Disorder -- genetics -- pathology medicine.medical_specialty ASD autism spectrum disorder Executive Function -- physiology Cognitive Neuroscience media_common.quotation_subject False belief Temporoparietal junction Magnetoencephalography -- methods Theory of Mind -- physiology behavioral disciplines and activities Temporal Lobe -- physiopathology 050105 experimental psychology NEPSY-II Developmental Neuropsychological Assessment Second Edition 03 medical and health sciences Spatial Processing mental disorders medicine Humans 0501 psychology and cognitive sciences mPFC medial prefrontal cortex MEG magnetoencephalography medicine.disease WMTB-C Working Memory Test Battery for Children lcsh:Neurophysiology and neuropsychology ToM theory of mind TD typically developing 030217 neurology & neurosurgery |
| Zdroj: | Developmental cognitive neuroscience, 34 Developmental Cognitive Neuroscience, Vol 34, Iss, Pp 139-147 (2018) Developmental Cognitive Neuroscience |
| Popis: | Highlights • First MEG study of neural underpinnings of theory of mind differences in autism. • Children with autism show decreased LTPJ activity from 300 to 375 and 425 to 500 ms. • Children with autism also show increased RIFG activity from 325 to 375 ms. • Co-incident lower LTPJ and higher RIFG activity implies compensatory use of RIFG. • Executive functions may augment impaired theory of mind in autism. The social impairments observed in children with autism spectrum disorder are thought to arise in part from deficits in theory of mind, the ability to understand other people’s thoughts and feelings. To determine the temporal-spatial dynamics of brain activity underlying these atypical theory-of-mind processes, we used magnetoencephalography to characterize the sequence of functional brain patterns (i.e. when and where) related to theory-of-mind reasoning in 19 high-functioning children with autism compared to 22 age- and sex-matched typically-developing children aged 8–12 during a false-belief (theory-of-mind) task. While task performance did not differ between the two groups, children with autism showed reduced activation in the left temporoparietal junction between 300–375 and 425–500 ms, as well as increased activation in the right inferior frontal gyrus from 325 to 375 ms compared to controls. The overlap in decreased temporoparietal junction activity and increased right inferior frontal gyrus activation from 325 to 375 ms suggests that in children with autism, the right inferior frontal gyrus may compensate for deficits in the temporoparietal junction, a neural theory-of-mind network hub. As the right inferior frontal gyrus is involved in inhibitory control, this finding suggests that children with autism rely on executive functions to bolster their false-belief understanding. |
| Databáze: | OpenAIRE |
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