Aberrant plasticity in Alzheimer's disease
| Autor: | Yoshihiro Ueda, Satoru Mori, Masaki Kondo, Kenji Nakajima, Ryou Fujii, Yoshio Imahori |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Central nervous system Disease Central nervous system disease Degenerative disease Alzheimer Disease medicine Humans Diacylglycerol kinase Aged Fluorodeoxyglucose Aged 80 and over Neuronal Plasticity General Neuroscience Middle Aged medicine.disease Frontal Lobe medicine.anatomical_structure Frontal lobe Case-Control Studies Female Alzheimer's disease Psychology medicine.drug Tomography Emission-Computed |
| Zdroj: | Neuroreport. 10(7) |
| ISSN: | 0959-4965 |
| Popis: | ALZHEIMER'S disease (AD) is a region-specific degenerative disease that mainly impairs the temporal and parietal lobes, with preservation of the frontal lobes until advanced stages of disease. Since [ 11 C]diacylglycerol PET facilitates examination of loci exhibiting plasticity, it was performed in eight patients with AD and six age-matched normal control subjects to evaluate frontal lobe function. [ 11 C]Diacylglycerol tomograms obtained from patients with AD demonstrated strong spotty incorporation of [ 11 C]diacylglycerol mainly in the frontal association areas. However, [ 18 F]fluorodeoxyglucose tomograms exhibited region-specific findings such as decreased CMRGlc in the parietotemporal association areas, which are involved in impairment of cognitive function. The strong spotty incorporation of [ 11 C]diacylglycerol suggested a compensatory plastic process in the frontal lobes in response to involvement by Alzheimer's disease of the posterior association areas. |
| Databáze: | OpenAIRE |
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