DNA damage tolerance
| Autor: | Ivan Psakhye, Dana Branzei |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
DNA Replication
0301 basic medicine Genetics DNA re-replication Replication timing DNA Repair DNA repair DNA replication Eukaryotic DNA replication Cell Biology Biology Pre-replication complex Cell biology 03 medical and health sciences Eukaryotic Cells 030104 developmental biology 0302 clinical medicine Control of chromosome duplication Animals Humans Origin recognition complex 030217 neurology & neurosurgery DNA Damage |
| Zdroj: | Current Opinion in Cell Biology. 40:137-144 |
| ISSN: | 0955-0674 |
| DOI: | 10.1016/j.ceb.2016.03.015 |
| Popis: | Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks. Cells use two general strategies to tolerate lesions: recombination to a homologous template, and trans-lesion synthesis with specialized polymerases. While key players of these processes have been outlined, much less is known on their choreography and regulation. Recent advances have uncovered principles by which DNA damage tolerance is regulated locally and temporally - in relation to replication timing and cell cycle stage -, and are beginning to elucidate the DNA dynamics that mediate lesion tolerance and influence chromosome structure during replication. |
| Databáze: | OpenAIRE |
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