CHR3: a Caenorhabditis elegans orphan nuclear hormone receptor required for proper epidermal development and molting
| Autor: | Marta Kostrouchova, J. E. Rall, Z Kostrouch, Michael Krause |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
DNA
Complementary Recombinant Fusion Proteins media_common.quotation_subject Morphogenesis Receptors Cytoplasmic and Nuclear Molting Biology Animals Genetically Modified Gene product Animals RNA Antisense RNA Messenger Cloning Molecular Metamorphosis Nuclear protein Caenorhabditis elegans Promoter Regions Genetic Molecular Biology Gene Genes Helminth Heat-Shock Proteins media_common Genetics Reporter gene integumentary system Gene Expression Regulation Developmental DNA Helminth biology.organism_classification Neuron-derived orphan receptor 1 Cell biology Larva Epidermis RNA Helminth Developmental Biology |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1477-9129 0950-1991 |
| DOI: | 10.1242/dev.125.9.1617 |
| Popis: | CHR3 is a Caenorhabditis elegans orphan nuclear hormone receptor highly homologous to Drosophila DHR3, an ecdysone-inducible gene product involved in metamorphosis. Related vertebrate factors include RORalpha/RZRalpha, RZRbeta and RevErb. Gel-shift studies show that CHR3 can bind the DR5-type hormone response sequence. CHR3 is a nuclear protein present in all blastomeres during early embryogenesis. During morphogenesis, both CHR3 protein and zygotically active reporter genes are detectable in epidermal cells and their precursors. Inhibition of the gene encoding CHR3 results in several larval defects associated with abnormal epidermal cell function, including molting and body size regulation, suggesting that CHR3 is an essential epidermal factor required for proper postembryonic development. |
| Databáze: | OpenAIRE |
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