Immunoglobulin G4‐related disease in a dog
| Autor: | Laura A. Snyder, Emily D. Rout, Lydia J. Colopy, Anne C. Avery, Kai‐Biu Shiu, A R. Moore |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Immunofixation
Pathology medicine.medical_specialty Immunology Case Report Disease Case Reports Immunoglobulin E Blood serum Fibrosis parasitic diseases medicine Eosinophilia lcsh:Veterinary medicine General Veterinary biology business.industry immunofixation medicine.disease IgG‐D biology.protein lcsh:SF600-1100 SMALL ANIMAL IgE Antibody Differential diagnosis medicine.symptom business eosinophilia |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of Veterinary Internal Medicine, Vol 33, Iss 6, Pp 2732-2738 (2019) |
| ISSN: | 1939-1676 0891-6640 |
| Popis: | Immunoglobulin G4‐related disease (IgG4‐RD), which affects many organ systems, has been recognized as a distinct clinical entity in human medicine for just over a decade but has not been previously identified in dogs. In humans, IgG4‐RD is characterized by diffuse IgG4‐positive lymphoplasmacytic infiltrates that commonly lead to increased serum concentrations of IgG4 and IgE, peripheral eosinophilia, tumorous swellings that often include the parotid salivary glands, obliterative phlebitis, and extensive fibrosis. Herein we describe the diagnosis, clinical progression, and successful treatment of IgG4‐RD in an 8‐year‐old female spayed Husky mixed breed dog. Immunoglobulin G4‐related disease should be considered as a differential diagnosis for dogs with vague clinical signs, lymphoplasmacytic swellings, restricted polyclonal gammopathy, eosinophilia or some combination of these findings. |
| Databáze: | OpenAIRE |
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