Enzymatic activity at the surface of biomaterials via supramolecular anchoring of peptides : the effect of material processing
| Autor: | Patricia Y. W. Dankers, Wilco P. J. Appel, E. W. Meijer |
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| Přispěvatelé: | Macro-Organic Chemistry, Macromolecular and Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Polymers and Plastics
RNase P Surface Properties Polyesters Supramolecular chemistry Nanofibers Bioengineering Biocompatible Materials Pyrimidinones macromolecular substances Microscopy Atomic Force Biomaterials Ribonucleases Materials Testing Materials Chemistry Solid-Phase Synthesis Techniques chemistry.chemical_classification Tissue Engineering Hydrogen bond technology industry and agriculture Biomaterial Combinatorial chemistry Electrospinning Solvent Supramolecular polymers Enzyme chemistry Solvents Peptides Biotechnology |
| Zdroj: | Macromolecular Bioscience, 11(12), 1706-1712. Wiley-VCH Verlag |
| ISSN: | 1616-5187 |
| Popis: | Supramolecular polymers allow for a modular approach to bioactive biomaterials. Here the effect of processing on the bioactivation of supramolecular biomaterials using a RNase S assay is investigated. Incorporation of S-peptides into supramolecular polymers by solvent casting shows a clear organic-solvent dependency. Although a significant release of the S-peptides is observed, RNase S activity can be measured indicating successful S-peptide surface immobilization. Additionally, the effect of electrospinning on the biomaterial's bioactivity is studied, showing that the fibrous meshes developed were bioactive. The results show the importance of solvent choice, and illustrate the potency of rendering supramolecular biomaterial films and meshes bioactive via a modular approach. |
| Databáze: | OpenAIRE |
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