Photodynamic Therapy Associated with a Blue Dye Papain-Based Gel and Evaluation of Its Degradation of Type I Collagen Fibers
| Autor: | R. A. Mesquita-Ferrari, Sergio Brossi Botta, Patricia Aparecida Ana, Gonçalves Mll, Fernandes Kps, Brugnera A Junior, de Araújo Prates R, Sandra Kalil Bussadori |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_treatment
Biomedical Engineering Photodynamic therapy In Vitro Techniques Collagen Type I 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship 0302 clinical medicine medicine In vitro study Organic chemistry Animals Humans Radiology Nuclear Medicine and imaging Analysis of Variance Blue dye Chromatography Photosensitizing Agents Chemistry 030206 dentistry Methylene Blue Papain Photochemotherapy Case-Control Studies Degradation (geology) Cattle Gels After treatment Type I collagen |
| Zdroj: | Photomedicine and laser surgery. 36(2) |
| ISSN: | 1557-8550 |
| Popis: | The aim of this in vitro study was to evaluate the degradation of type I collagen fibers after treatment with a papain-based gel associated with a blue dye (PapaMBlue™) for use in antimicrobial photodynamic therapy.For such, 60 bioabsorbable membrane sponge discs were used. Group 1 was the negative control group. In groups 2, 3, and 4, the papain-based gel PapaMBlue gel was applied all over the samples for 4 min and irradiated using red laser (660 ± 10 nm) with 15, 30, and 40 J/cmNeither classic Papacarie™ nor the modified product with a photosensitizing agent (PapaMBlue) promoted collagen degradation.The irradiation of methylene blue added to papain gel with red light did not alter the chemical structure of type I collagen. |
| Databáze: | OpenAIRE |
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