Urinary oxylipin signature as biomarkers to monitor the allograft function during the first six months post-renal transplantation
| Autor: | Valérie Bultel-Poncé, Ignacio De las Heras-Gómez, Angel Gil-Izquierdo, Thierry Durand, Federico Ferreres, Teresa Casas-Pina, Pedro Martínez-Hernández, Jean-Marie Galano, Luisa Jimeno, Santiago Llorente, Sonia Medina |
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| Přispěvatelé: | Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Hospital Univeristario Virgen de la Arrixaca, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Nephrology medicine.medical_specialty MESH: Oxylipins Urinary system [SDV]Life Sciences [q-bio] MESH: Allografts Isoprostanes Prostanoids Urine Biochemistry Gastroenterology MESH: Kidney Transplantation 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Physiology (medical) Internal medicine medicine Humans Oxylipins chemistry.chemical_classification Inflammation Kidney MESH: Humans business.industry MESH: Tandem Mass Spectrometry Oxylipin Allografts Kidney Transplantation 3. Good health Transplantation 030104 developmental biology medicine.anatomical_structure Renal transplant chemistry Thromboxanes Oxidative stress Lipidomics MESH: Biomarkers business 030217 neurology & neurosurgery Biomarkers Polyunsaturated fatty acid |
| Zdroj: | Free Radical Biology and Medicine Free Radical Biology and Medicine, Elsevier, 2020, 146, pp.340-349. ⟨10.1016/j.freeradbiomed.2019.11.010⟩ |
| ISSN: | 1873-4596 0891-5849 |
| Popis: | International audience; Oxylipins such as isoprostanes (IsoPs), prostaglandins (PGs) and thromboxanes (TXs) are lipid mediators derived from the oxidation of polyunsaturated fatty acids, which regulate the magnitude of oxidative stress and inflammation processes and play an important role in pathophysiological processes in the kidney. A total of 36 oxylipins were analyzed by UHPLC-QqQ-MS/MS in the urine of 41 renal recipients from cadaveric donors of the Nephrology Unit of the University Hospital Virgen de la Arrixaca during the first six months after renal transplantation, in order to investigate several candidate oxylipins as more accurate and predictive biomarkers in renal transplantation than classical biological variables. A decrease in nine PGs, mostly from the AA-D pathway (p |
| Databáze: | OpenAIRE |
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