The Importance of Hemorheology and Patient Anatomy on the Hemodynamics in the Inferior Vena Cava
| Autor: | Kenneth I. Aycock, Robert L. Campbell, Keefe B. Manning, Frank C. Lynch, Brent A. Craven |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Vena Cava Filters 0206 medical engineering Blood viscosity Biomedical Engineering Hemodynamics Vena Cava Inferior 02 engineering and technology 030204 cardiovascular system & hematology Inferior vena cava 03 medical and health sciences 0302 clinical medicine medicine Newtonian fluid Shear stress Humans Thrombus Chemistry Models Cardiovascular Thrombosis Anatomy Blood flow medicine.disease 020601 biomedical engineering medicine.vein Hemorheology cardiovascular system Radiology |
| Zdroj: | Annals of Biomedical Engineering. 44:3568-3582 |
| ISSN: | 1573-9686 0090-6964 |
| Popis: | Inferior vena cava (IVC) filters have been used for nearly half a century to prevent pulmonary embolism in at-risk patients. However, complications with IVC filters remain common. In this study, we investigate the importance of considering the hemorheological and morphological effects on IVC hemodynamics by simulating Newtonian and non-Newtonian blood flow in three IVC models with varying levels of geometric idealization. Partial occlusion by an IVC filter and a thrombus is also considered. More than 99% of the infrarenal IVC volume is found to contain flow in the nonlinear region of the shear rate–viscosity curve for blood (less than 100 s−1) in the unoccluded IVCs. Newtonian simulations performed using the asymptotic viscosity for blood over-predict the non-Newtonian Reynolds numbers by more than a factor of two and under-predict the mean wall shear stress (WSS) by 28–54%. Agreement with the non-Newtonian simulations is better using a characteristic viscosity, but local WSS errors are still large (up to 50%) in the partially occluded cases. Secondary flow patterns in the IVC also depend on the viscosity model and IVC morphological complexity. Non-Newtonian simulations required only a marginal increase in computational expense compared with the Newtonian simulations. We recommend that future studies of IVC hemodynamics consider the effects of hemorheology and IVC morphology when accurate predictions of WSS and secondary flow features are desired. |
| Databáze: | OpenAIRE |
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