Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE
| Autor: | Gary G. R. Green, Soumya Singha Roy, Lyrelle S. Lloyd, Simon B. Duckett, Steven R. Coombes, Alexandra M. Olaru |
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| Rok vydání: | 2016 |
| Předmět: |
Zeeman effect
010405 organic chemistry Chemistry Metals and Alloys General Chemistry 010402 general chemistry Spin isomers of hydrogen 01 natural sciences Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials symbols.namesake Nuclear magnetic resonance Transfer (computing) Materials Chemistry Ceramics and Composites symbols Singlet state Atomic physics Signal amplification |
| Zdroj: | Chemical Communications (Cambridge, England) |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c6cc02020h |
| Popis: | SABRE is harnessed to create a hyperpolarised long-lived state in 2-aminothiazole with >90% efficiency and 27 seconds lifetime. The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the signal amplification by reversible exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90% efficiency into the new state, which in this case has a 27 second lifetime. |
| Databáze: | OpenAIRE |
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