Importance of serum basal tryptase levels in children with insect venom allergy
| Autor: | E. Arik Yilmaz, Betul Buyuktiryaki, Ayfer Tuncer, Cansin Sackesen, Umit Murat Sahiner, Suleyman Tolga Yavuz, B. E. Sekerel, Ozge Soyer |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Allergy medicine.medical_specialty Adolescent Immunology Tryptase Venom Biology Logistic regression Severity of Illness Index Gastroenterology Basal (phylogenetics) Interquartile range Internal medicine Hypersensitivity medicine Humans Immunology and Allergy Child Arthropod Venoms Insect Bites and Stings Prognosis medicine.disease Systemic reaction ROC Curve Case-Control Studies Child Preschool Insect venom allergy biology.protein Female Tryptases |
| Zdroj: | Allergy. 68:386-391 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.12098 |
| Popis: | Background The importance of serum basal tryptase (sBT) levels on patients with venom allergy is highlighted in recent adulthood studies. The aim of this study was to evaluate the sBT levels of venom-allergic children with varying severity of clinical reactions. We also aimed to document the association between sBT levels and severe systemic reactions (SR). Methods Serum basal tryptase levels were estimated by UniCAP (Pharmacia & Upjohn, Uppsala, Sweden). Children who suffered from large local reaction (LLR) or SR after insect stings were included along with healthy control subjects without a history of any local or SR after insect stings. Results A total of 128 children (55 with SR, 18 with LLR, and 55 age and sex-matched control subjects) with a median age of 8.9 years (range 3.2–17.4) were enrolled. Severe SR was encountered in 24 (44%) patients with SRs. The median level of sBT in children with SRs (median, interquartile range) [4.2 μg/l (3.6–4.9)] was significantly higher than in children with LLRs [3.1 μg/l (2.5–4.0)] and healthy control subjects [2.9 μg/l (2.3–3.4)] (P |
| Databáze: | OpenAIRE |
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