Serum syndecan-4 is associated with nonalcoholic fatty liver disease

Autor: Yu Cheng Luo, An Na Dai, Feng Gan Cheng, Jian-Gao Fan, Zhao Shan Xu, Li Li Zhang, Hong Xia Chen, Zi Hua Wang, Shu Jing Xia, Li Zhong Tang, Wen Hua Li
Rok vydání: 2021
Předmět:
Zdroj: Journal of digestive diseasesREFERENCES. 22(9)
ISSN: 1751-2980
Popis: OBJECTIVES The accelerated shedding of extracellular domains of syndecan-4 (SDC4) is associated with central obesity and insulin resistance, while the association between serum SDC4 and nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to examine the association between SDC4 and NAFLD. METHODS Adults undergoing a health examination from 1 June 2019 to 31 December 2019 were enrolled. A diagnosis of NAFLD was made with an abdominal ultrasound. Logistic regression models and the receiver operating characteristic (ROC) curves were used to evaluate the role of SDC4 in predicting NAFLD. RESULTS In total, 533 eligible participants were finally enrolled, among them 157 (29.46%) had NAFLD. The proportion of patients with NAFLD increased with the increasing quartiles of serum SDC4. With the increase of serum SDC4 levels, metabolic features including waist circumference, serum triglyceride, total cholesterol, fasting blood glucose, fasting insulin and homeostasis model assessment of insulin resistance were significantly increased. SDC4 was an independent factor for NAFLD (odds ratio 1.963, 95% confidence interval [CI] 1.628-2.367, P
Databáze: OpenAIRE
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