Water Exchange Rate Constant as a Biomarker of Treatment Efficacy in Patients With Brain Metastases Undergoing Stereotactic Radiosurgery
| Autor: | Kimberly L. Desmond, Arjun Sahgal, Sofia Chavez, Colleen Bailey, Gregory J. Czarnota, Radoslaw Rola, Hany Soliman, Greg J. Stanisz, Anne L. Martel, Hatef Mehrabian |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Intracellular Fluid Male Cancer Research Time Factors medicine.medical_treatment Contrast Media Apoptosis Water exchange Radiosurgery Models Biological 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Reaction rate constant Body Water Biomarkers Tumor medicine Humans Radiology Nuclear Medicine and imaging In patient Prospective Studies Prospective cohort study Aged Aged 80 and over Radiation Brain Neoplasms business.industry Tumor shrinkage Extracellular Fluid Middle Aged Magnetic Resonance Imaging Treatment efficacy Tumor Burden Treatment Outcome Oncology Disease Progression Biomarker (medicine) Female business Nuclear medicine 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 98:47-55 |
| ISSN: | 0360-3016 |
| Popis: | Purpose This study was designed to evaluate whether changes in metastatic brain tumors after stereotactic radiosurgery (SRS) can be seen with quantitative MRI early after treatment. Methods and Materials Using contrast-enhanced MRI, a 3-water-compartment tissue model consisting of intracellular (I), extracellular-extravascular (E), and vascular (V) compartments was used to assess the intra–extracellular water exchange rate constant ( k IE ), efflux rate constant ( k ep ), and water compartment volume fractions ( M 0,I , M 0,E , M 0,V ). In this prospective study, 19 patients were MRI-scanned before treatment and 1 week and 1 month after SRS. The change in model parameters between the pretreatment and 1-week posttreatment scans was correlated to the change in tumor volume between pretreatment and 1-month posttreatment scans. Results At 1 week k IE differentiated ( P R =−0.76, P k IE and tumor volume change 1 month after treatment. Other model parameters had lower correlation ( M 0,E ) or no correlation ( k ep , M 0,V ). Conclusions This is the first study that measured k IE early after SRS, and it found that early changes in k IE (1 week after treatment) highly correlated with long-term tumor response and could predict the extent of tumor shrinkage at 1 month after SRS. |
| Databáze: | OpenAIRE |
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