Metabolomics reveals plausible interactive effects between dairy product consumption and metabolic syndrome in humans
| Autor: | Edward D. Karoly, Corinne Marmonier, Frédéric Capel, Chrystèle Jouve, Jean Ferrières, Corinne Malpuech-Brugère, Gregory A. Michelotti, Vanina Bongard, Jean Louis Sébédio, Jean Paul Rigaudière |
|---|---|
| Přispěvatelé: | Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UMR 1027, Centre Hospitalier Universitaire de Toulouse, Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Santé et de la Recherche Médicale (INSERM), Metabolon INC, Centre National Interprofessionnel de l'Economie Laitière [Paris] (CNIEL), Centre National Interprofessionnel de l'Economie Laitiere (CNIEL), France, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Université de Toulouse, Centre National Interprofessionnel de l'Economie Laitière (CNIEL) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Metabolite [SDV]Life Sciences [q-bio] Lysophospholipids 030209 endocrinology & metabolism Critical Care and Intensive Care Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Metabolomics medicine Metabolome Humans Food science Aged 2. Zero hunger chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Untargeted metabolomics business.industry Lipidomic Fatty acid Middle Aged Clinical parameters medicine.disease Sphingolipid Metabolic syndrome Diet Metabolic pathway chemistry Female business Dairy products |
| Zdroj: | Clinical Nutrition Clinical Nutrition, Elsevier, In press, ⟨10.1016/j.clnu.2019.06.013⟩ Clinical Nutrition, In press, ⟨10.1016/j.clnu.2019.06.013⟩ Clinical Nutrition, Elsevier, 2019, ⟨10.1016/j.clnu.2019.06.013⟩ |
| ISSN: | 0261-5614 1532-1983 |
| Popis: | [Epub ahead of print]; BACKGROUND & AIMS: Metabolic syndrome (MetS) induces major disturbances in plasma metabolome, reflecting abnormalities of several metabolic pathways. Recent evidences have demonstrated that the consumption of dairy products may protect from MetS, but the mechanisms remains unknown. The present study aimed at identify how the consumption of different types of dairy products could modify the changes in plasma metabolome during MetS. METHODS: In this observational study, we analyzed how the consumption of dairy products could modify the perturbations in the plasma metabolome induced by MetS in a sample of 298 participants (61 with MetS) from the French MONA LISA survey. Metabolomic profiling was analyzed with UPLC-MS/MS. RESULTS: Subjects with MetS exhibited major changes in plasma metabolome. Significant differences in plasma levels of branched chain amino acids, gamma-glutamyl amino acids, and metabolites from arginine and proline metabolism were observed between healthy control and Mets subjects. Plasma levels of many lipid species were increased with MetS (mono- and diacylglycerols, eicosanoids, lysophospholipids and lysoplasmalogens), with corresponding decreases in short chain fatty acids and plasmalogens. The consumption of dairy products, notably with a low fat content (milk and fresh dairy products), altered metabolite profiles in plasma from MetS subjects. Specifically, increasing consumption of dairy products promoted accumulation of plasma C15:0 fatty acid and was inversely associated to some circulating lysophospholipids, sphingolipids, gamma-glutamyl amino acids, leukotriene B4 and lysoplasmalogens. CONCLUSIONS: the consumption of low fat dairy products could mitigate some of the variations induced by MetS. |
| Databáze: | OpenAIRE |
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