Effect of Iron Oxide Nanoparticles and Amoxicillin on Bacterial Growth in the Presence of Dissolved Organic Carbon
| Autor: | Kelley Current, Niluka Dissanayake, Sherine Obare |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) humic acid 010501 environmental sciences Bacterial growth medicine.disease_cause 01 natural sciences General Biochemistry Genetics and Molecular Biology Article antibiotics Microbiology 03 medical and health sciences chemistry.chemical_compound Dissolved organic carbon medicine Humic acid engineered nanoparticles iron oxide nanoparticles emerging contaminants amoxicillin bacteria lcsh:QH301-705.5 0105 earth and related environmental sciences Pollutant chemistry.chemical_classification biology Contamination biology.organism_classification 030104 developmental biology lcsh:Biology (General) chemistry 13. Climate action Staphylococcus aureus Environmental chemistry Iron oxide nanoparticles Bacteria |
| Zdroj: | Biomedicines Biomedicines, Vol 5, Iss 3, p 55 (2017) Biomedicines; Volume 5; Issue 3; Pages: 55 |
| ISSN: | 2227-9059 |
| Popis: | The impact of emerging contaminants in the presence of active pharmaceutical pollutants plays an important role in the persistence and activity of environmental bacteria. This manuscript focuses on the impact of amoxicillin functionalized iron oxide nanoparticles on bacterial growth, in the presence of dissolved organic carbon (humic acid). The impact of these emerging contaminants individually and collectively on the growth profiles of model gram positive and negative bacteria was tracked for 24 h. Results indicate exposure to subinhibitory concentrations of amoxicillin bound iron oxide nanoparticles, in the presence of humic acid, increase bacterial growth in Pseudomonas aeruginosa and Staphylococcus aureus. Accelerated bacterial growth was associated with an increase in iron ions, which have been shown to influence upregulation of cellular metabolism. Though iron oxide nanoparticles are often regarded as benign, this work demonstrates the distinguishable impact of amoxicillin bound iron oxide nanoparticles in the presence of dissolved organic carbon. The results indicate differential impacts of combined contaminants on bacterial growth, having potential implications for environmental and human health. |
| Databáze: | OpenAIRE |
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